SmartCrystal® formulation of hydrophobic GHA has higher skin penetration than its hydrophilic form. Nanocrystal formulation approach can improve the saturation solubility and skin penetration profile of the compound. The enhancement of penetration of GHA from nanocrystal was also confirmed in human skin. Better penetration of GHA from nanocrystal in the deep skin tissue is beneficial […]

Cell mediated drug delivery is explored widely to target drugs to particular organs (e.g., spleen, lungs etc.) in cancer, tissue inflammation or in bone injury. The highly mobile cells like mononuclear phagocytes (dendritic cells, Sertoli cells, monocytes and macrophages), neutrophils and lymphocytes loaded drug nanocarriers are exploited as trojan horses for drug delivery. Cell mediated […]

RNAi therapeutics, has quickly been established as a robust and effective gene silencing strategy and has several distinct advantages over traditional pharmaceutical drugs. The reason of the limited number of siRNA delivery systems in clinical trials is certainly the complexity of the approach. It is easier to administer naked or modified siRNA than to develop […]

Lipid nanoparticles especially SLNs and NLCs are well trusted and long researched (almost 25 years) as a drug delivery platform in pharma for various biomedical applications. Literature has extensively discussed and recognized the role of excipient in formulation, stability, in vitro and in vivo effects of the lipid nanoparticles. Biocompatibility of lipid nanoparticles is highly […]

Unique properties of graphene are attracting great attention of scientists for various biomedical applications. Several attempts were already made to functionalize the surface of graphene oxide with polymers, surfactants and other chemical moiety in attempt to increase cellular uptake, to target particular organ, to reduce toxicity and to increase solubility. Literature report confirms all most […]

Coenzyme Q10 (CoQ10) is a promising candidate in the pharmaceutical and nutraceutical field. However, it has a poor bioavailability due to its very low aqueous solubility and high molecular weight. The purpose of this review is to discuss the different types of CoQ10 drug delivery systems (DDS) ranging from the simple oily dispersions to the […]

Drug nanocrystals are a formulation principle for systemic and also, intracellular delivery of poorly soluble drugs. Their production by bottom-up techniques (precipitation – hydrosols,Nanomorph) and by top-down techniques (bead milling –NanoCrystal®, high pressure homogenization – DissoCubes®, NANOEDGE®) is briefly described, representing the first generation of nanocrystals. The second generation, the smart- Crystal®, is produced by […]

Solid lipid nanoparticles (SLNs) have gained momentum over the three decades due to its role in improving bioavailability/ drug stability, controlled and targeted delivery, and as vaccine adjuvants. The excellent biocompatibility of lipid nanoparticles and ease of formulation without using toxic solvents are the main reasons for their popularity over polymeric nanoparticles. The performance of […]

Nanosuspensions and lipid nanoparticles are very promising drug delivery systems for overcoming drug-related challenges, and to develop better therapeutic systems for patients. Both systems have a wide application in biomedicine as well as in other fields of science. This chapter is a first compilation where only large-scale manufacturing as per industry standard for both drug […]

Early years are proof of nanoparticle developments and understanding basic mechanisms. With no doubt, nanotechnology-based drug delivery systems are very effective to achieve improved therapeutic effects in vivo and properties in vitro. Drug discovery programs are generating pharmacologically potential drugs but they suffer from solubility, stability, and toxicity. Nanoparticle engineering could find various solutions to […]