Large-scale manufacturing of nanoparticles—An industrial outlook

Nanosuspensions and lipid nanoparticles are very promising drug delivery systems for overcoming drug-related challenges, and to develop better therapeutic systems for patients. Both systems have a wide application in biomedicine as well as in other fields of science. This chapter is a first compilation where only large-scale manufacturing as per industry standard for both drug delivery systems has been discussed. It is critical and important to control formulation and process-related variables to produce nanoformulations of desired quality. Timely communication with regulatory bodies, equipment suppliers, and excipient suppliers is beneficial to understand the impact of changed parameters on the quality of a product. Similarly, it is equally important to break the silos within an organization and to foster collaborations between different experts, especially formulation scientists, engineers, regulatory scientists, analysts, and packaging experts. This will speed up the process of nanoparticles formulation and process development. This chapter guides scientists, engineers, and other experts on the industrial outlook of nanoparticle production, requirements, and challenges

https://doi.org/10.1016/B978-0-12-821222-6.00004-X