SmartCrystal® formulation of hydrophobic GHA has higher skin penetration than its hydrophilic form. Nanocrystal formulation approach can improve the saturation solubility and skin penetration profile of the compound. The enhancement of penetration of GHA from nanocrystal was also confirmed in human skin. Better penetration of GHA from nanocrystal in the deep skin tissue is beneficial as the molecule has antioxidant and anti-aging property.
https://doi.org/10.2174/2210303107666170929115817
Improved Skin Penetration of Hydrophobic Glycyrrhetinic Acid SmartCrystal® Compared to Its Water Soluble Salt
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