The challenges in treating AIDS, malaria, tuberculosis, chagas and others can be reduced to certain limit by use of correct formulation type i.e., nanosuspensions. These diseases demand attention of pharma R & D’s to invest resources for developing effective drug delivery systems. Many published reports confirmed that the nanocrystal would serve as an ideal industrially […]
The development and characterization of lipid nanoparticle of stavudine with robust particle size control, stability and superior targeting of antiretroviral drug molecules is reported. The blood clearance, lymph kinetic, gamma imaging and biodistribution for radiolabeled pure drug, blank and drug loaded nanoparticles were carried out in rats. The prepared lipid nanoparticles showed enhanced levels in […]
Poor solubility of new drugs and their related low oral bioavailability and general delivery problems are becoming a major challenge. Nanocrystals being a kind of “universal” formulation approach for these molecules are reviewed in this paper regarding the industrial feasibility, i.e., industrially available production processes (bottom-up and top-down technologies), regulatory aspects and nanotoxicology. This article […]
This article successfully reviews practical considerations to manufacture nano-crystalline suspensions by top-down processes. The factors like formulation Composition, selection of milling steps and application of engineering principles are key aspects. In order to make a successful nano-crystalline suspension as a drug delivery system, the formulation and process engineering, have to be addressed based on physico-chemical […]
Quercetin nanocrystals were successfully fabricated by means of three methods, namely high-pressure homogenization, bead milling and cavi-precipitation; and the nanocrystals obtained from these three methods were compared. Bead milling fabricated the smallest particle size whereas high pressure homogenization gave the lowest polydispersity index. However, the saturation solubility of products from both was not significantly different.https://doi.org/10.1016/j.ejpb.2011.08.006
Middle-chain triglyceride mixed with glyceryl tripalmitate or with carnauba wax, carnauba wax alone and middle-chain triglyceride alone formed stable lutein-loaded lipid nanocarriers. Particle size was affected by the lipid type. However, when the particles are incorporated in a viscous dermal formulation, diffusion velocity of the particles is reduced and even 40°C should be no problem […]
Lutein nanocrystals could be produced by high pressure homogenization with a size as low as about 400 nm just applying the pre-milling procedure. This opens the perspective of a fast production of cosmetic and pharmaceutical lutein nanocrystals, in contrast to many drugs requiring additionally 20 cycles of high-pressure homogenization. Compared to the poorly water-soluble powder, […]
Flavonoids have many positive effects on various cell layers of the skin (e.g., anti-oxidant, anti-allergic and anti-inflammatory effects). However, the limiting factor of the use of flavonoids is their low water solubility. To overcome the low solubility, apigenin nanosuspensions were prepared using the combination technology (CT), i.e., bead milling and subsequently high-pressure homogenization. Distinct reduction […]
PEG has a multifaceted application ranging from molecular solubilization in conventional formulations to stealth in nanoparticles and implantable devices. Modifications of native PEG with different and well-defined structural features are currently under progress and can have a significant contribution in drug delivery. Literature published in this arena has focused upon applications of PEG. A proper […]
Nano-sized particles can cross cellular membranes by nonphagocytic mechanisms, which may facilitate their access to sites within cells and tissues which are not routinely encountered, further contributing to uncertainty surrounding their toxic potential. In this context, proteins adsorbed onto the surface of intravenously administered particles, liposomes and variety of drug delivery agents often play a […]
