Quercetin nanocrystals were successfully fabricated by means of three methods, namely high-pressure homogenization, bead milling and cavi-precipitation; and the nanocrystals obtained from these three methods were compared. Bead milling fabricated the smallest particle size whereas high pressure homogenization gave the lowest polydispersity index. However, the saturation solubility of products from both was not significantly different.
https://doi.org/10.1016/j.ejpb.2011.08.006